Nexa DSR
Rabeprazole Sodium (Enteric Coated) & Domperidone (SR) CapsulesMARKETER: Syngex Pharma Pvt Ltd
SALT COMPOSITION: Domperidone + Rabeprazole
USES OF NEXA DSR TABLET
- Manage peptic ulcer
- Manage Gastro-Esophageal Reflux Disease (GERD) (not responding to therapy with rabeprazole alone)
HOW NEXA DSR TABLET WORKS
NEXA DSR CAPSULE reduces stomach ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid and domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions.
INTRODUCTION ABOUT NEXA DSR TABLET
NEXA DSR CAPSULE is a combination of Domperidone and Rabeprazole which belongs to the group of medicines called Dopamine Antagonists and Proton pump inhibitors respectively. NEXA DSR CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) among patients who have not responded adequately to rabeprazole alone.
GERD is a chronic digestive disease in which the stomach acid frequently flows into the oesophagus leading to irritation of the lining of the food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
NEXA DSR CAPSULE can also be used to manage peptic ulcers caused by H. pylori infection or NSAIDs use. Peptic ulcers are painful sores that develop on the linings of the stomach, oesophagus or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.
Along with NEXA DSR CAPSULE, try to eat less spicy foods and drink plenty of water or fluids. Avoid smoking or alcohol consumption as it may aggravate your existing condition.
Patients receiving long-term management with NEXA DSR CAPSULE should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors. Before taking NEXA DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. Your doctor may reduce the dose or suggest an alternative therapy.
NEXA DSR CAPSULE is not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years). It should be used with caution in elderly patients (above 65 years of age).
The most common side effects of taking NEXA DSR CAPSULE are nausea, vomiting, stomach pain, diarrhoea or constipation. Consult your doctor if any of these symptoms worsen.
DIRECTIONS FOR USE
Take NEXA DSR CAPSULE as advised by your physician. Swallow NEXA DSR CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF NEXA DSR TABLET
COMMON SIDE EFFECTS:
- Nausea or vomiting
- Diarrhea, constipation, stomach pain, flatulence
- Cough, sore throat, runny nose
- Back pain
- Weakness or loss of strength
- Flu like symptoms
- Sleeplessness
- Headache, dizziness
- Infection
- Dry mouth
- Benign polyps in the stomach
UNCOMMON SIDE EFFECTS :
- Nervousness
- Sleepiness
- Bronchitis (inflammation of the bronchus)
- Sinusitis (inflammation of the sinus)
- Indigestion, belching in the stomach (excess air accumulation in the stomach)
- Muscle pain, leg pain, joint pain
- Fracture of hip, wrist or spine
- Urinary tract infection
- Chest pain
- Chills, fever
- Decreased libido
- Anxiety
- Itching
- Breast pain or tenderness
- Galactorrhea (milk discharge from the breast)
RARE SIDE EFFECTS:
- Changes in white blood cells
- Signs of low platelet count in blood (easy bruising or bleeding)
- Hypersensitivity (swelling of the face, eyelids, mouth, tongue or throat, decreases in blood pressure, difficulty in breathing)
- Loss of appetite
- Anorexia (an eating disorder)
- Depression
- Visual disturbance
- Gastritis (inflammation of the stomach lining)
- Stomatitis (sore mouth)
- Sweating
- Taste disturbance
- Hepatitis (inflammation of the liver caused by viral infection)
- Jaundice (yellowing of the skin and whites of the eyes)
- Hepatic encephalopathy (brain damage caused by liver infection)
- Bullous reactions (severe skin reactions with fluid filled blisters)
- Interstitial nephritis (inflammation of the kidneys)
- Weight gain
- Stop taking NEXA DSR CAPSULE and contact your doctor immediately if you experience the following side effects:
- Severe allergic reaction (sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
- Symptoms of liver problems (yellow skin, dark urine and tiredness)
- Severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
- Seizures
- Involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
- Heart rhythm disorders (rapid or irregular heartbeat)
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhoea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much alcohol. Consult your doctor if the symptom did not improve.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Consult your doctor if the symptom did not improve.
Constipation:
Eat fibre rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
NEXA DSR CAPSULE is not recommended for use during pregnancy. Consult your doctor before taking NEXA DSR CAPSULE.
BREASTFEEDING
NEXA DSR CAPSULE is not recommended for use in breast-feeding women. Consult your doctor before taking NEXA DSR CAPSULE.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience sleepiness, confusion or less control over your movements. Consult your doctor before taking NEXA DSR CAPSULE.
ALCOHOL
Avoid consumption of alcohol while taking NEXA DSR CAPSULE, as it could aggravate your existing condition.
KIDNEY
NEXA DSR CAPSULE is not recommended for use in patients with kidney impairment. Consult your doctor before taking NEXA DSR CAPSULE.
LIVER
NEXA DSR CAPSULE is not recommended for use in patients with moderate or severe liver impairment and it should be used with caution in patients with liver problems. Consult your doctor before taking NEXA DSR CAPSULE.
ALLERGY
Do not take NEXA DSR CAPSULE if you are allergic to Domperidone or Rabeprazole.
HEART DISEASE
NEXA DSR CAPSULE is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure. Consult your doctor before taking NEXA DSR CAPSULE.
OTHERS
NEXA DSR CAPSULE is not recommended for use if you:
- Have bloody stools or bleeding in the gut
- Have blockage or tear in the intestines
- Have severe fluid or electrolyte disturbances
- Have prolactinoma (a non-cancerous tumour of pituitary gland)
- Have phenylketonuria (a metabolic disorder)
- Have problem that causes low levels of potassium or magnesium or high levels of potassium in the blood
- Have hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption
Before taking NEXA DSR CAPSULE, inform your physician if you:
- Have osteoporosis
- Have vitamin B12 deficiency (sore tongue, mouth ulcers, pale skin, depression)
- Are going to test Chromogranin A level
Use in paediatrics:
NEXA DSR CAPSULE is not recommended for use in children and adolescents (aged less than 18 years) due to lack of safety and effectiveness. Consult your doctor for advice.
Use in geriatrics:
NEXA DSR CAPSULE should be taken with caution in elderly patients (aged 65 years or above). Consult your doctor before taking NEXA DSR CAPSULE.
INTERACTIONS
Drug-Drug interactions:
Before taking NEXA DSR CAPSULE inform to your doctor, if you are taking any of these medicines:
- Other medicines used to manage gastrointestinal problems (Ex. cisapride, dolasetron, prucalopride, diphemanil)
- Medicines used to manage heart problems or hypertension (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
- Medicines used to manage HIV infection (Ex. atazanavir, nelfinavir, saquinavir)
- Medicines used to manage hepatitis C (Ex. telaprevir)
- Antipsychotics (used to manage mental illness) Ex. haloperidol, pimozide, sertindole
- Antidepressants (used to manage depression) Ex. escitalopram or citalopram
- Antibiotics (used to manage bacterial infections) Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin
- Medicines used to manage malaria (Ex. halofantrine, lumefantrine)
- Antihistamines (used to manage allergies) Ex. mizolastine, mequitazine
- Medicines used to manage cancer (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
- Methotrexate (used to manage cancer and auto-immune disease)
- Bepridil (used to manage hypertension)
- Methadone (used to relieve pain)
- Iron salts (used to manage iron deficiency anaemia)
- Tacrolimus or mycophenolate mofetil (used to manage graft rejection)
- Ketoconazole and itraconazole (used to manage fungal infection)
- Pentamidine (used to manage parasite infections)
- Warfarin (used to manage and manage clots)
OVERDOSAGE
If you or anyone else takes too much of NEXA DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of NEXA DSR CAPSULE might include altered consciousness, agitation, convulsions, disorientation, sleepiness and extrapyramidal reactions (such as rigidity, tremor, drooling etc.).
SYNOPSIS
Drug : Domperidone, Rabeprazole
Pharmacological Category : Dopamine antagonist, Proton pump inhibitor
Therapeutic Indication : Peptic ulcer, GERD
Dosage Forms : Tablet, Capsule
MORE INFORMATION
- Keep NEXA DSR CAPSULE out of reach of children
- Store NEXA DSR CAPSULE at room temperature
FAQs ABOUT NEXA DSR TABLET
Yes. NEXA DSR CAPSULE can cause diarrhoea in some individuals. Keep yourself hydrated by drinking plenty of fluids, oral electrolytes and juices. Do not self-manage diarrhoea if it persists for a longer period. Contact your doctor for advice.
No. NEXA DSR CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) and does not cause acid reflux. If you experience any unusual symptoms after taking NEXA DSR CAPSULE, kindly consult your doctor.
NEXA DSR CAPSULE may rarely cause damage to your kidneys (Ex. interstitial nephritis). However, inform your doctor immediately if you experience any signs of kidney damage such as dark urine, blood in urine, painful urination or lower abdominal discomfort during management with NEXA DSR CAPSULE. Your doctor might reduce the dose or suggest an alternative therapy.
Take NEXA DSR CAPSULE on an empty stomach or as advised by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose of NEXA DSR CAPSULE and duration of therapy for you, depending upon your age, body weight and health condition.
No. NEXA DSR CAPSULE is not recommended for use in children and adolescents (below 18 years) due to lack of safety and effectiveness. Kindly consult a child’s doctor if your child experiences any symptoms of gastro-esophageal reflux disease or peptic ulcer (such as nausea, vomiting, discomfort in upper stomach, stomach pain, heartburn, burping, etc.).